Founding member of the
Zuse community and the FTVT

Research

Applied research for human, animal and environmental health. We are specialized in the development of new diagnostic detection methods and new analytical methods. We are also developing new therapies for animal health (e.g. horses and dogs).

We link our competences in the fields of cell biology, in vitro diagnostics, biotechnology and optical analytics internally with applications of our veterinary clinic, externally with needs of large and small companies. Our department with the laboratory for food testing also creates the interface for healthy food.

As a business-oriented research institution in the Zuse community, we are the link between science and industry. Our application-oriented research and development of processes and products thus enables rapid implementation in the market.

An overview of current investments andcurrent funding in research and consulting by the state of Thuringia can be found at the bottom of this page.

Cell Biology Department

Basis for targeted diagnostics and individualized therapy

We create innovative solutions for diagnostics through new applications in the fields of next generation sequencing (NGS), fluorescence microscopy (immunofiltration) and flow cytometry. We develop tailor-made applications for the precise and efficient analysis of cells and microorganisms. In this way, we support the improvement of veterinary diagnostics and lay the foundations for targeted and individualized therapies. We also adapt established analytical methods to customer-specific requirements for the quality control of food and drinking water.

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Current research topics include

  • Biomarker screening for veterinary tumor diagnostics.
  • NGS-based diagnostics of pathogens and tumors
  • Application development for fluorescence microscopy and flow cytometry
  • Animal-free production of antibodies (artificial immune sera) in cell culture using in-vitro immunization
  • Production of recombinant therapeutic antibodies for horses

Biotechnology Division

Microarray development & production

The focus is on the development, validation and production of single and multiparameter assays for all applications in diagnostics and life sciences.

Equipped with state-of-the-art microarray spotters and microdispensers, our department specializes in the development and production of microarray-based assays.

We support customers worldwide with an exclusive microarray printing service starting from array design to data analysis.

From feasibility study to optimization, verification and validation to pilot production, we offer all phases of development.

After successful project implementation, we are available as a partner for ISO-certified contract manufacturing.

Department Bioinstruments/ Device Development

optical analytics meets artificial intelligence

Contactless optical analysis methods have a wide range of applications in the field of process and laboratory analysis.

We develop customized hardware and software solutions for innovative methods of hyperspectral imaging, UV, VIS, NIR and IR spectroscopy as well as gas analysis using ion mobility spectrometry. We also develop applications for microscopic analysis and applications using time-gated fluorescence detection.

For spectroscopic and chemometric services, our excellently equipped laboratory and the know-how of our experts are at your disposal.

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Fields of application

  • Hyperspectral measurements (400 nm – 2,500 nm)
  • Measurement of absorption, reflection and transmission
  • Scattered light measurements
  • time-resolved fluorescence spectroscopy
  • Near Infrared Spectroscopy
  • Development of chemometric models for NIR spectroscopy
  • Development of AI-based evaluation methods for hyperspectral measurement data
  • Radiation optical simulations
  • CAD modeling and 3D printing

In vitro diagnostics department

from antigen to point-of-care test / ELISA

Our department specializes in the development of immunological tests for veterinary and human medical applications. The focus is on assay developments for use in the diagnostic laboratory (ELISA) as well as on tests for on-site analysis, such as point-of-care tests (lateral flow assay).

We develop and validate complete test systems, including individual diagnostic components such as monoclonal antibodies and recombinant proteins. Novel detection markers such as fluorescent nanoparticles are also used in this process.

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Fields of application

  • Development and production of antigens and antibodies
  • Development and production of lateral flow assays/ ELISA
  • Preparations for the transfer to production

Veterinary clinic

new therapies and diagnostics for large and small animals

For 25 years, scientists at the Veterinary Clinic have been involved in application developments in orthopedics and internal medicine.

Current focus in orthopedics is the development of autologous implants as replacements for articular cartilage and ligaments as well as instruments and implants for fracture treatment by means of osteosynthesis.

The internal medicine topics focus on the development of multiplex assays for molecular allergy diagnostics for horses as well as the improvement of tumor diagnostics in dogs using new biomarkers from liquid biopsy and their combination with findings from imaging procedures. Artificial intelligence algorithms are used for this purpose.

We are an active member of the ProAnimalLife and WildLifePro research networks.

Department and test laboratory for food testing

Analysis of food, cosmetics & environment

For the safety of food, water, but also cosmetics, research into new detection methods and procedures is needed. Reductions in analysis times or improvements in detection sensitivity play a major role here.

In addition to our activities as a laboratory service provider for food safety and consumer protection, we therefore also conduct extensive research and development of new methods at fzmb.

Not only large and medium-sized companies benefit from these results, but also the numerous craft enterprises in the region.

Our laboratory is accredited by the German Accreditation Body (DAkkS) in accordance with DIN EN 17025 and certified in accordance with DIN EN ISO 9001.

current investments in research

Structure Platform Next Generation Sequencing

The COVID-19 pandemic highlighted the need for a rapid response to the emergence of new, pathogenic agents and/or pathogen variants.

At fzmb, we want to meet this challenge. In order to identify and characterize new pathogens (variants) more quickly, we are establishing a next generation sequencing platform. Using this high-throughput method, we can visualize even the smallest genetic changes (such as mutations) in a short time. On this basis, we can subsequently develop improved/adapted diagnostics such as rapid tests (lateral flow assays) for self-testing or ELISAs/microarraries for laboratory diagnostics.

The project, which is supported by the Free State of Thuringia, is co-financed by funds from the European Union within the framework of the REACT-EU Fund. The realization was carried out after a limited invitation to tender without a competition in accordance with ThürVVöA as a sub-threshold supply service. For this purpose, an NG sequencer from Illumina and the necessary computing hardware from Godyo GmbH were purchased. An FPLC (Äkta pure 25 M) from Cytiva was purchased for sample preparation and separation. For quality control, a TapeStation from Agilent), for DNA quantification a Qubit from Thermo Fisher Scientific and for a PCR cycler (TAdvanced from Analytik Jena) were procured. An Arpege170 cryogenic container was purchased through VWR for sample storage.

Expansion of the “Highly Specific Antibodies” technology platform

The emergence of new, pathogenic agents and/or pathogen variants requires rapid responses. We are taking up this challenge and investing in the development of specific antibodies for new pathogens. On this basis, we can subsequently develop, for example, improved/adapted diagnostics such as rapid tests.

The following equipment was procured for the expansion of the “Highly Specific Antibodies” technology platform at the fzmb: An electrofusion and electroporation generator (Fisher Scientific GmbH, Schwerte) was procured for the preparation of cells for transfection. For the selection and characterization of antibody-producing cells, a fluorescence microscope (Thunder Imager 3D Assay, Leica Mikrosysteme GmbH, Wetzlar, Germany) including components and accessories, a microscope stage with accessories (Thorlabs GmbH, Beikirchen, Germany) and the corresponding air purification system (KKT Kratochwill GmbH, Mühlhausen, Germany) were procured. The project, which is supported by the Free State of Thuringia, is co-financed by funds from the European Union within the framework of the REACT-EU Fund. The realization was carried out after a limited invitation to tender without a competition in accordance with ThürVVöA as a sub-threshold supply service.

current promotions in the consultation

Innovation voucher for the establishment of a new R&D collaboration

Immunotherapies use the body’s own immune system to effectively fight inflammatory processes or cancer, for example. The “Preparation of an R&D cooperation project for the development of an immunotherapy for specific bone diseases” project funded by the Free State of Thuringia is co-financed by funds from the European Union. The objectives of the innovation assistance include preliminary studies, intensive research on the status of these diseases and their current therapeutic options, market analyses, etc.

Entrepreneurial accompaniment – Subsidy according to consulting guideline

The fzmb GmbH is not only a research institute but also acts as a medium-sized company. In order to cooperate even more successfully with partners in foreign markets, we use intensive consulting and process support by independent management consultants. This project is supported by RKW Thüringen GmbH.

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current state funding into research